ESTADÍSTICAS NFL
| No. | Jugador | Equipo | Yardas | Fecha | Rival |
|---|
| 1 | Flipper Anderson | Rams | 336 | 1989-11-26 | Saints |
| 2 | Billy Cannon | Oilers | 330 | 1961-12-10 | NY Titans |
| 3 | Calvin Johnson+ | Lions | 329 | 2013-10-27 | Cowboys |
| 4 | Adrian Peterson | Vikings | 315 | 2007-11-04 | Chargers |
| 5 | Stephone Paige | Chiefs | 309 | 1985-12-22 | Chargers |
| 6 | Priest Holmes | Chiefs | 307 | 2002-11-24 | Seahawks |
| 7 | Antonio Brown | Steelers | 306 | 2015-11-08 | Raiders |
| 8 | Jim Benton | Rams | 303 | 1945-11-22 | Lions |
| | Josh Jacobs | Raiders | 303 | 2022-11-27 | Seahawks |
| 10 | Cloyce Box | Lions | 302 | 1950-12-03 | Colts |
| | Saquon Barkley | Eagles | 302 | 2024-11-24 | Rams |
| 12 | Julio Jones | Falcons | 300 | 2016-10-02 | Panthers |
| 13 | Jerry Rice+ | 49ers | 299 | 1995-12-18 | Vikings |
| 14 | Jerome Harrison | Browns | 298 | 2009-12-20 | Chiefs |
| | Le’Veon Bell | Steelers | 298 | 2016-12-11 | Bills |
| 16 | Jamal Lewis | Ravens | 295 | 2003-09-14 | Browns |
| 17 | Herschel Walker | Cowboys | 292 | 1986-12-14 | Eagles |
| 18 | Jimmy Smith | Jaguars | 291 | 2000-09-10 | Ravens |
| 19 | Jim Brown+ | Browns | 289 | 1961-11-19 | Eagles |
| 20 | Terrell Owens+ | 49ers | 288 | 2000-12-17 | Bears |
| | Jamaal Charles | Chiefs | 288 | 2012-09-23 | Saints |
| 22 | John Taylor | 49ers | 286 | 1989-12-11 | Rams |
| | Marshall Faulk+ | Rams | 286 | 2000-10-15 | Falcons |
| | Jonathan Taylor | Colts | 286 | 2025-11-09 | Falcons |
| 25 | Chris Johnson | Titans | 284 | 2009-09-20 | Texans |
| 26 | Walter Payton+ | Bears | 281 | 1977-11-20 | Vikings |
| 27 | Delvin Williams | 49ers | 279 | 1976-11-07 | Redskins |
| | Saquon Barkley | Giants | 279 | 2019-12-22 | Redskins |
| 29 | Corey Dillon | Bengals | 278 | 2000-10-22 | Broncos |
| 30 | Priest Holmes | Chiefs | 277 | 2001-12-09 | Raiders |
| 31 | Ollie Matson+ | Cardinals | 276 | 1954-11-28 | Steelers |
| | Corey Dillon | Bengals | 276 | 1997-12-04 | Oilers |
| | Tiki Barber | Giants | 276 | 2002-12-28 | Eagles |
| | Todd Gurley | Rams | 276 | 2017-12-24 | Titans |
| 35 | O.J. Simpson+ | Bills | 273 | 1976-11-25 | Lions |
| | Shaun Alexander | Seahawks | 273 | 2001-11-11 | Raiders |
| | Andre Johnson+ | Texans | 273 | 2012-11-18 | Jaguars |
| 38 | Charley Hennigan | Oilers | 272 | 1961-10-13 | Patriots |
| | Doug Martin | Buccaneers | 272 | 2012-11-04 | Raiders |
| 40 | LaDainian Tomlinson+ | Chargers | 271 | 2002-12-01 | Broncos |
| 41 | Del Shofner | Giants | 269 | 1962-10-28 | Redskins |
| | Tyreek Hill | Chiefs | 269 | 2020-11-29 | Buccaneers |
| 43 | Thurman Thomas+ | Bills | 268 | 1991-09-01 | Dolphins |
| | Julio Jones | Falcons | 268 | 2017-11-26 | Buccaneers |
| 45 | Jerry Butler | Bills | 267 | 1979-09-23 | Jets |
| | Marshall Faulk+ | Colts | 267 | 1998-11-29 | Ravens |
| 47 | Ja’Marr Chase | Bengals | 266 | 2022-01-02 | Chiefs |
| 48 | Chuck Foreman | Vikings | 265 | 1976-10-24 | Eagles |
| | Lee Evans | Bills | 265 | 2006-11-19 | Texans |
| | Amari Cooper | Browns | 265 | 2023-12-24 | Texans |
| 51 | James Brooks | Bengals | 264 | 1986-12-07 | Patriots |
| | Derrick Henry | Titans | 264 | 2020-10-18 | Texans |
| | Ja’Marr Chase | Bengals | 264 | 2024-11-07 | Ravens |
| | Jahmyr Gibbs | Lions | 264 | 2025-11-23 | Giants |
