ESTADÍSTICAS NFL
| No. | Corredor | Equipo | Yardas | Fecha | Rival |
|---|
| 1 | Adrian Peterson | Vikings | 296 | 2007-11-04 | Chargers |
| 2 | Jamal Lewis | Ravens | 295 | 2003-09-14 | Browns |
| 3 | Jerome Harrison | Browns | 286 | 2009-12-20 | Chiefs |
| 4 | Corey Dillon | Bengals | 278 | 2000-10-22 | Broncos |
| 5 | Walter Payton+ | Bears | 275 | 1977-11-20 | Vikings |
| 6 | O.J. Simpson+ | Bills | 273 | 1976-11-25 | Lions |
| 7 | Shaun Alexander | Seahawks | 266 | 2001-11-11 | Raiders |
| 8 | Jamaal Charles | Chiefs | 259 | 2010-01-03 | Broncos |
| 9 | Saquon Barkley | Eagles | 255 | 2024-11-24 | Rams |
| 10 | DeMarco Murray | Cowboys | 253 | 2011-10-23 | Rams |
| | Jonathan Taylor | Colts | 253 | 2021-01-03 | Jaguars |
| 12 | Mike Anderson | Broncos | 251 | 2000-12-03 | Saints |
| | Doug Martin | Buccaneers | 251 | 2012-11-04 | Raiders |
| 14 | Spec Sanders | NY Yankees | 250 | 1947-10-24 | Chi. Rockets |
| | O.J. Simpson+ | Bills | 250 | 1973-09-16 | Patriots |
| | Derrick Henry | Titans | 250 | 2021-01-03 | Texans |
| 17 | Willie Ellison | Rams | 247 | 1971-12-05 | Saints |
| 18 | Corey Dillon | Bengals | 246 | 1997-12-04 | Oilers |
| 19 | Jonathan Taylor | Colts | 244 | 2025-11-09 | Falcons |
| 20 | Cookie Gilchrist | Bills | 243 | 1963-12-08 | Jets |
| | LaDainian Tomlinson+ | Chargers | 243 | 2003-12-28 | Raiders |
| 22 | Derrick Henry | Titans | 238 | 2018-12-06 | Jaguars |
| 23 | Jim Brown+ | Browns | 237 | 1957-11-24 | Rams |
| | Jim Brown+ | Browns | 237 | 1961-11-19 | Eagles |
| | Emmitt Smith+ | Cowboys | 237 | 1993-10-31 | Eagles |
| | Barry Sanders+ | Lions | 237 | 1994-11-13 | Buccaneers |
| 27 | Le’Veon Bell | Steelers | 236 | 2016-12-11 | Bills |
| 28 | Doug Martin | Buccaneers | 235 | 2015-11-22 | Eagles |
| 29 | Fred Taylor | Jaguars | 234 | 2000-11-19 | Steelers |
| | Tiki Barber | Giants | 234 | 2006-12-30 | Redskins |
| 31 | Jamaal Charles | Chiefs | 233 | 2012-09-23 | Saints |
| 32 | Bobby Mitchell+ | Browns | 232 | 1959-11-15 | Redskins |
| | Jim Brown+ | Browns | 232 | 1963-09-22 | Cowboys |
| 34 | Arian Foster | Texans | 231 | 2010-09-12 | Colts |
| 35 | Josh Jacobs | Raiders | 229 | 2022-11-27 | Seahawks |
| 36 | Ricky Williams | Dolphins | 228 | 2002-12-01 | Bills |
| | Clinton Portis | Broncos | 228 | 2002-12-29 | Cardinals |
| | Chris Johnson | Titans | 228 | 2009-11-01 | Jaguars |
| | Beanie Wells | Cardinals | 228 | 2011-11-27 | Rams |
| 40 | O.J. Simpson+ | Bills | 227 | 1975-09-28 | Steelers |
| | Napoleon Kaufman | Raiders | 227 | 1997-10-19 | Broncos |
| | Priest Holmes | Ravens | 227 | 1998-11-22 | Bengals |
| 43 | Jamaal Charles | Chiefs | 226 | 2012-12-23 | Colts |
| 44 | Leonard Fournette | Jaguars | 225 | 2019-09-29 | Broncos |
| 45 | Adrian Peterson | Vikings | 224 | 2007-10-14 | Bears |
| | Knowshon Moreno | Broncos | 224 | 2013-11-24 | Patriots |
| 47 | Tommy Wilson | Rams | 223 | 1956-12-16 | Packers |
| | Jim Brown+ | Browns | 223 | 1963-11-03 | Eagles |
| | Willie Parker | Steelers | 223 | 2006-12-07 | Browns |
| 50 | Greg Bell | Rams | 221 | 1989-09-24 | Packers |
| | Gerald Riggs | Redskins | 221 | 1989-09-17 | Eagles |
| | Bo Jackson | Raiders | 221 | 1987-11-30 | Seahawks |
