| No. | Jugador | Tackleadas para Pérdida | Años | Equipo(s) |
|---|---|---|---|---|
| 1 | Terrell Suggs | 202 | 2003-2019 | Bal, Az, KC |
| 2 | Calais Campbell | 196 | 2008-2025 | Az, Jax, Bal, Atl, Mia |
| 3 | J.J. Watt | 195 | 2011-2022 | Hou, Az |
| 4 | Lavonte David | 177 | 2012-2025 | TB |
| Von Miller | 177 | 2011-2025 | Den, LAR, Buf, Was | |
| 6 | Aaron Donald | 176 | 2014-2023 | LAR |
| 7 | Cameron Jordan | 175 | 2011-2025 | NO |
| Julius Peppers+ | 175 | 2002-2018 | Car, Chi, GB | |
| 9 | Jared Allen+ | 171 | 2004-2015 | KC, Min, Chi, Car |
| DeMarcus Ware+ | 171 | 2005-2016 | Dal, Den | |
| 11 | Jason Taylor+ | 151 | 1997-2011 | Mia, Was, NYJ |
| 12 | Myles Garrett | 149 | 2017-2025 | Cle |
| 13 | John Abraham | 148 | 2000-2014 | NYJ, Atl, Az |
| Khalil Mack | 148 | 2014-2025 | Oak, Chi, LAC | |
| 15 | Cameron Heyward | 142 | 2011-2025 | Pit |
| 16 | Danielle Hunter | 140 | 2015-2025 | Min, Hou |
| 17 | Brian Urlacher+ | 138 | 2000-2012 | Chi |
| 18 | T.J. Watt | 136 | 2017-2025 | Pit |
| 19 | Trent Cole | 133 | 2005-2016 | Phi, Ind |
| Maxx Crosby | 133 | 2019-2025 | Raid | |
| 21 | Michael Bennett | 132 | 2009-2019 | TB, Sea, Phi, NE, Dal |
| Justin Houston | 132 | 2011-2023 | KC, Ind, Bal, Car, Mia | |
| 23 | Michael Strahan+ | 131 | 1993-2007 | NYG |
| 24 | Clay Matthews | 130 | 2009-2019 | GB, LAR |
| Ndamukong Suh | 130 | 2010-2022 | Det, Mia, LAR, TB, Phi | |
| 26 | Dwight Freeney+ | 128 | 2002-2017 | Ind, SD, Az, Atl, Sea, Det |
| Brandon Graham | 128 | 2010-2025 | Phi | |
| James Harrison | 128 | 2002-2017 | Pit, Cin, NE | |
| 29 | Karlos Dansby | 127 | 2004-2017 | Az, Mia, Cle, Cin |
| Jason Pierre-Paul | 127 | 2010-2025 | NYG, TB, Bal, NO, Mia | |
| 31 | Joey Porter | 124 | 1999-2011 | Pit, Mia, Az |
| 32 | Carlos Dunlap | 123 | 2010-2022 | Cin, Sea, KC |
| 33 | Chandler Jones | 121 | 2012-2022 | NE, Az, LV |
| Mario Williams | 121 | 2006-2016 | Hou, Buf, Mia | |
| 35 | Jadeveon Clowney | 120 | 2014-2025 | Hou, Sea, Ten, Cle, Bal, Car, Dal |
| Ryan Kerrigan | 120 | 2011-2021 | Was, Phi | |
| 37 | Justin Smith | 119 | 2001-2014 | Cin, SF |
| 38 | Demario Davis | 116 | 2012-2025 | NYJ, Cle, NO |
| 39 | Andre Carter | 115 | 2001-2013 | SF, Was, NE, Oak |
| 40 | Kevin Williams | 113 | 2003-2015 | Min, Sea, NO |
| 41 | London Fletcher | 109 | 1998-2013 | SLR, Buf, Was |
| Robert Quinn | 109 | 2011-2022 | LAR, Mia, Dal, Chi, Phi | |
| 43 | DeMarcus Lawrence | 108 | 2014-2025 | Dal, Sea |
| Robert Mathis | 108 | 2003-2016 | Ind | |
| 45 | Bobby Wagner | 107 | 2012-2025 | Sea, LAR, Was |
| 46 | Tamba Hali | 105 | 2006-2017 | KC |
| 47 | Derrick Johnson | 103 | 2005-2018 | KC, Oak |
| Kyle Williams | 103 | 2006-2018 | Buf | |
| 49 | Justin Tuck | 102 | 2005-2015 | NYG, Oak |
| 50 | Geno Atkins | 100 | 2010-2020 | Cin |
| 51 | Chris Jones | 99 | 2016-2025 | KC |
| Ray Lewis+ | 99 | 1996-2012 | Bal | |
| Trevor Pryce | 99 | 1997-2010 | Den, Bal, NYJ | |
| Cameron Wake | 99 | 2009-2019 | Mia, Ten | |
| 55 | Brian Burns | 98 | 2019-2025 | Car, NYG |
| James Farrior | 98 | 1997-2011 | NYJ, Pit | |
| Aaron Schobel | 98 | 2001-2009 | Buf | |
| 58 | Lance Briggs | 97 | 2003-2014 | Chi |
| DeForest Buckner | 97 | 2016-2025 | SF, Ind | |
| Everson Griffen | 97 | 2010-2021 | Min, Dal, Det | |
| 61 | Joey Bosa | 96 | 2016-2025 | LAC, Buf |
| Jerry Hughes | 96 | 2010-2024 | Ind, Buf, Hou | |
| Willie McGinest | 96 | 1994-2008 | NE, Cle | |
| 64 | Matt Judon | 95 | 2016-2025 | Bal, NE, Atl, Mia, Buf |
| Patrick Kerney | 95 | 1999-2009 | Atl, Sea | |
| Adewale Ogunleye | 95 | 2001-2010 | Mia, Chi, Hou |
