| No. | Jugador | Equipo | Tackleadas para pérdida | Temporada |
|---|---|---|---|---|
| 1 | J.J. Watt | Texans | 39 | 2012 |
| 2 | Myles Garrett | Browns | 33 | 2025 |
| 3 | J.J. Watt | Texans | 29 | 2014 |
| J.J. Watt | Texans | 29 | 2015 | |
| 5 | Von Miller | Broncos | 28 | 2012 |
| Chandler Jones | Cardinals | 28 | 2017 | |
| Maxx Crosby | Raiders | 28 | 2025 | |
| 8 | DeMarcus Ware+ | Cowboys | 27 | 2008 |
| 9 | DeMarcus Ware+ | Cowboys | 26 | 2011 |
| 10 | Aaron Donald | Rams | 25 | 2018 |
| 11 | Michael Strahan+ | Giants | 24 | 2001 |
| 12 | Kendrell Bell | Steelers | 23 | 2001 |
| Michael Strahan+ | Giants | 23 | 2003 | |
| Jason Pierre-Paul | Giants | 23 | 2011 | |
| Robert Quinn | Rams | 23 | 2013 | |
| Justin Houston | Chiefs | 23 | 2014 | |
| Khalil Mack | Raiders | 23 | 2015 | |
| T.J. Watt | Steelers | 23 | 2020 | |
| Maxx Crosby | Raiders | 23 | 2023 | |
| Danielle Hunter | Vikings | 23 | 2023 | |
| 21 | Jamir Miller | Browns | 22 | 2001 |
| J.J. Watt | Texans | 22 | 2013 | |
| Aaron Donald | Rams | 22 | 2015 | |
| Maxx Crosby | Raiders | 22 | 2022 | |
| Myles Garrett | Browns | 22 | 2024 | |
| Brian Burns | Giants | 22 | 2025 | |
| 27 | Jessie Armstead | Giants | 21 | 1999 |
| Hugh Douglas | Eagles | 21 | 2000 | |
| Cornelius Griffin | Redskins | 21 | 2004 | |
| Cameron Wake | Dolphins | 21 | 2010 | |
| DeMarcus Ware+ | Cowboys | 21 | 2010 | |
| Jared Allen+ | Vikings | 21 | 2011 | |
| Lavonte David | Buccaneers | 21 | 2013 | |
| Ndamukong Suh | Lions | 21 | 2014 | |
| Jadeveon Clowney | Texans | 21 | 2017 | |
| Danielle Hunter | Vikings | 21 | 2018 | |
| Nick Bosa | 49ers | 21 | 2021 | |
| T.J. Watt | Steelers | 21 | 2021 | |
| Khalil Mack | Chargers | 21 | 2023 | |
| 40 | Warren Sapp+ | Buccaneers | 20 | 2000 |
| Hugh Douglas | Eagles | 20 | 2002 | |
| Dwight Freeney+ | Colts | 20 | 2002 | |
| John Abraham | Falcons | 20 | 2008 | |
| Jared Allen+ | Vikings | 20 | 2008 | |
| Justin Tuck | Giants | 20 | 2008 | |
| LaMarr Woodley | Steelers | 20 | 2009 | |
| Terrell Suggs | Ravens | 20 | 2011 | |
| Lavonte David | Buccaneers | 20 | 2012 | |
| Calais Campbell | Jaguars | 20 | 2018 | |
| Luke Kuechly+ | Panthers | 20 | 2018 | |
| Aaron Donald | Rams | 20 | 2019 | |
| Micah Parsons | Cowboys | 20 | 2021 | |
| Jeremiah Owusu-Koramoah | Browns | 20 | 2023 | |
| Will Anderson | Texans | 20 | 2025 | |
| Tuli Tuipulotu | Chargers | 20 | 2025 | |
| 56 | Ray Lewis+ | Ravens | 19 | 1999 |
| Willie McGinest | Patriots | 19 | 1999 | |
| Bryant Young+ | 49ers | 19 | 1999 | |
| Brian Urlacher+ | Bears | 19 | 2002 | |
| Adewale Ogunleye | Dolphins | 19 | 2003 | |
| Charles Grant | Saints | 19 | 2004 | |
| Jared Allen+ | Chiefs | 19 | 2007 | |
| Shawne Merriman | Chargers | 19 | 2007 | |
| Alex Brown | Bears | 19 | 2008 | |
| Terrell Suggs | Ravens | 19 | 2008 | |
| Jared Allen+ | Vikings | 19 | 2009 | |
| Andre Carter | Redskins | 19 | 2009 | |
| Charles Johnson | Panthers | 19 | 2011 | |
| Von Miller | Broncos | 19 | 2011 | |
| Mario Williams | Bills | 19 | 2014 | |
| Chris Jones | Chiefs | 19 | 2018 | |
| Shaquil Barrett | Buccaneers | 19 | 2019 | |
| Aaron Donald | Rams | 19 | 2021 | |
| Von Miller | Broncos/Rams | 19 | 2021 | |
| Nick Bosa | 49ers | 19 | 2022 | |
| Frankie Luvu | Panthers | 19 | 2022 | |
| T.J. Watt | Steelers | 19 | 2023 | |
| Trey Hendrickson | Bengals | 19 | 2024 | |
| T.J. Watt | Steelers | 19 | 2024 | |
| 80 | Kevin Greene+ | Panthers | 18 | 1999 |
| Duane Clemons | Chiefs | 18 | 2000 | |
| Jason Gildon | Steelers | 18 | 2000 | |
| La’Roi Glover | Saints | 18 | 2000 | |
| Michael Strahan+ | Giants | 18 | 2005 | |
| Julius Peppers+ | Panthers | 18 | 2006 | |
| Derrick Johnson | Chiefs | 18 | 2007 | |
| Joey Porter | Dolphins | 18 | 2008 | |
| Darnell Dockett | Cardinals | 18 | 2009 | |
| John Abraham | Falcons | 18 | 2010 | |
| Clay Matthews | Packers | 18 | 2010 | |
| Terrell Suggs | Ravens | 18 | 2010 | |
| Michael Bennett | Buccaneers | 18 | 2012 | |
| Aldon Smith | 49ers | 18 | 2012 | |
| Adrian Clayborn | Buccaneers | 18 | 2013 | |
| Aaron Donald | Rams | 18 | 2014 | |
| Ryan Kerrigan | Redskins | 18 | 2014 | |
| Michael Bennett | Seahawks | 18 | 2015 | |
| Olivier Vernon | Dolphins | 18 | 2015 | |
| Ryan Kerrigan | Redskins | 18 | 2016 | |
| Cameron Jordan | Saints | 18 | 2018 | |
| J.J. Watt | Texans | 18 | 2018 | |
| Joey Bosa | Chargers | 18 | 2019 | |
| Roquan Smith | Bears | 18 | 2020 | |
| Myles Garrett | Browns | 18 | 2022 | |
| Daron Payne | Commanders | 18 | 2022 | |
| J.J. Watt | Cardinals | 18 | 2022 | |
| Micah Parsons | Cowboys | 18 | 2023 | |
| Jonathan Greenard | Vikings | 18 | 2024 | |
| Andrew Van Ginkel | Vikings | 18 | 2024 |
