| No. | Jugador | Equipo | Tackleadas Combinadas | Fecha | Rival |
|---|---|---|---|---|---|
| 1 | David Harris | Jets | 24 | 2007-11-04 | Redskins |
| Luke Kuechly+ | Panthers | 24 | 2013-12-22 | Saints | |
| 3 | Damien Covington | Bills | 22 | 1997-10-26 | Broncos |
| Kiko Alonso | Bills | 22 | 2013-10-13 | Bengals | |
| 5 | Ray Lewis+ | Ravens | 21 | 1997-09-14 | Giants |
| London Fletcher | Bills | 21 | 2004-10-10 | Jets | |
| Rodney Harrison | Patriots | 21 | 2004-10-31 | Steelers | |
| Zach Thomas+ | Dolphins | 21 | 2006-12-17 | Bills | |
| Pat Angerer | Colts | 21 | 2011-09-25 | Steelers | |
| Kwon Alexander | Buccaneers | 21 | 2016-12-18 | Cowboys | |
| Alex Singleton | Broncos | 21 | 2022-10-17 | Chargers | |
| Roquan Smith | Ravens | 21 | 2023-11-12 | Browns | |
| 13 | Victor Green | Jets | 20 | 1996-10-20 | Bills |
| Eric Brown | Broncos | 20 | 1999-09-26 | Buccaneers | |
| Derrick Brooks+ | Buccaneers | 20 | 2000-11-26 | Bills | |
| Derrick Brooks+ | Buccaneers | 20 | 2001-09-30 | Vikings | |
| Donnie Edwards | Chargers | 20 | 2004-12-05 | Broncos | |
| London Fletcher | Bills | 20 | 2005-11-13 | Chiefs | |
| Patrick Willis+ | 49ers | 20 | 2007-12-23 | Buccaneers | |
| Jerod Mayo | Patriots | 20 | 2008-11-13 | Jets | |
| London Fletcher | Redskins | 20 | 2012-10-07 | Falcons | |
| Bobby Wagner | Seahawks | 20 | 2021-09-19 | Titans | |
| Kamu Grugier-Hill | Texans | 20 | 2021-12-05 | Colts | |
| Jordyn Brooks | Seahawks | 20 | 2022-01-09 | Cardinals | |
| Alex Singleton | Broncos | 20 | 2022-12-25 | Rams | |
| Jordyn Brooks | Dolphins | 20 | 2025-11-16 | Commanders | |
| Germaine Pratt | Colts | 20 | 2025-11-23 | Chiefs | |
| 28 | Junior Seau+ | Chargers | 19 | 1994-10-23 | Broncos |
| Jeff Herrod | Colts | 19 | 1994-12-11 | Patriots | |
| Eric Hill | Cardinals | 19 | 1995-09-19 | Panthers | |
| Derrick Brooks+ | Buccaneers | 19 | 1996-09-15 | Broncos | |
| Hardy Nickerson | Buccaneers | 19 | 1997-10-26 | Vikings | |
| Micheal Barrow | Giants | 19 | 2003-09-15 | Cowboys | |
| Roman Phifer | Patriots | 19 | 2003-10-12 | Giants | |
| Zach Thomas+ | Dolphins | 19 | 2003-11-02 | Colts | |
| Andra Davis | Browns | 19 | 2005-09-18 | Packers | |
| Brian Urlacher+ | Bears | 19 | 2006-10-16 | Cardinals | |
| Donnie Edwards | Chargers | 19 | 2006-12-03 | Bills | |
| Curtis Lofton | Falcons | 19 | 2009-09-27 | Patriots | |
| London Fletcher | Redskins | 19 | 2011-10-30 | Bills | |
| Paul Worrilow | Falcons | 19 | 2013-11-03 | Panthers | |
| Paul Worrilow | Falcons | 19 | 2013-11-10 | Seahawks | |
| Danny Trevathan | Broncos | 19 | 2015-11-08 | Colts | |
| Shaquille Leonard | Colts | 19 | 2018-09-16 | Redskins | |
| Bobby Wagner | Seahawks | 19 | 2019-09-22 | Saints | |
| Quay Walker | Packers | 19 | 2023-09-28 | Lions | |
| Blake Cashman | Texans | 19 | 2023-11-19 | Cardinals | |
| Grant Stuard | Colts | 19 | 2024-10-20 | Dolphins | |
| Devin White | Raiders | 19 | 2025-12-07 | Broncos | |
| 50 | Hardy Nickerson | Buccaneers | 18 | 1994-09-11 | Colts |
| Robert Jones | Cowboys | 18 | 1994-12-24 | Giants | |
| Greg Biekert | Raiders | 18 | 1996-11-10 | Buccaneers | |
| Victor Green | Jets | 18 | 1996-12-22 | Dolphins | |
| Jessie Armstead | Giants | 18 | 1997-10-05 | Cowboys | |
| Brian Williams | Packers | 18 | 1999-09-12 | Raiders | |
| Rob Fredrickson | Cardinals | 18 | 1999-11-07 | Jets | |
| Zach Thomas+ | Dolphins | 18 | 2001-09-23 | Raiders | |
| Ray Lewis+ | Ravens | 18 | 2001-12-02 | Colts | |
| Kelly Gregg | Ravens | 18 | 2002-09-30 | Broncos | |
| Ray Lewis+ | Ravens | 18 | 2002-09-30 | Broncos | |
| Ben Taylor | Browns | 18 | 2003-10-26 | Patriots | |
| Tommy Hendricks | Dolphins | 18 | 2003-11-09 | Titans | |
| Donnie Edwards | Chargers | 18 | 2003-11-16 | Broncos | |
| Ray Lewis+ | Ravens | 18 | 2003-11-30 | 49ers | |
| Zach Thomas+ | Dolphins | 18 | 2004-12-26 | Browns | |
| Brad Kassell | Titans | 18 | 2005-01-02 | Lions | |
| Donnie Edwards | Chargers | 18 | 2005-12-24 | Chiefs | |
| Patrick Willis+ | 49ers | 18 | 2007-11-25 | Cardinals | |
| Patrick Willis+ | 49ers | 18 | 2007-12-02 | Panthers | |
| Napoleon Harris | Chiefs | 18 | 2007-12-30 | Jets | |
| Patrick Willis+ | 49ers | 18 | 2008-10-05 | Patriots | |
| London Fletcher | Redskins | 18 | 2009-09-13 | Giants | |
| Jamar Williams | Bears | 18 | 2009-12-06 | Rams | |
| Jerod Mayo | Patriots | 18 | 2010-10-17 | Ravens | |
| Donte Whitner | Bills | 18 | 2010-11-28 | Steelers | |
| Kavell Conner | Colts | 18 | 2011-10-03 | Buccaneers | |
| Michael Griffin | Titans | 18 | 2012-09-16 | Chargers | |
| NaVorro Bowman | 49ers | 18 | 2012-09-23 | Vikings | |
| Vontaze Burfict | Bengals | 18 | 2012-12-30 | Ravens | |
| Sean Lee | Cowboys | 18 | 2013-09-29 | Chargers | |
| Patrick Willis+ | 49ers | 18 | 2013-12-23 | Falcons | |
| Chris Borland | 49ers | 18 | 2014-11-02 | Rams | |
| Paul Posluszny | Jaguars | 18 | 2015-09-27 | Patriots | |
| Sean Lee | Cowboys | 18 | 2016-12-11 | Giants | |
| B.J. Goodson | Giants | 18 | 2017-09-10 | Cowboys | |
| Sean Lee | Cowboys | 18 | 2017-12-10 | Giants | |
| Luke Kuechly+ | Panthers | 18 | 2019-09-12 | Buccaneers | |
| Eric Kendricks | Vikings | 18 | 2021-11-07 | Ravens | |
| Devin White | Buccaneers | 18 | 2021-11-14 | Football Team | |
| Kamu Grugier-Hill | Texans | 18 | 2022-09-11 | Colts | |
| Foyesade Oluokun | Jaguars | 18 | 2022-11-27 | Ravens | |
| Josey Jewell | Broncos | 18 | 2022-12-04 | Ravens | |
| Rayshawn Jenkins | Jaguars | 18 | 2022-12-18 | Cowboys | |
| Nick Bolton | Chiefs | 18 | 2022-12-24 | Seahawks | |
| Bobby Wagner | Seahawks | 18 | 2023-09-10 | Rams | |
| Devin Bush Jr. | Seahawks | 18 | 2023-12-31 | Steelers | |
| Roquan Smith | Ravens | 18 | 2024-10-21 | Buccaneers | |
| Jamien Sherwood | Jets | 18 | 2024-12-08 | Dolphins | |
| Budda Baker | Cardinals | 18 | 2024-12-08 | Seahawks | |
| Jordyn Brooks | Dolphins | 18 | 2025-09-29 | Jets | |
| Elandon Roberts | Raiders | 18 | 2025-10-19 | Chiefs |
