| No. | Jugador | Sacks | Años | Equipo(s) |
|---|---|---|---|---|
| 1 | Bruce Smith+ | 200.0 | 1985-2003 | Buf, Was |
| 2 | Reggie White+ | 198.0 | 1985-2000 | Phi, GB, Car |
| 3 | Kevin Greene+ | 160.0 | 1985-1999 | LAR, Pit, Car, SF |
| 4 | Julius Peppers+ | 159.5 | 2002-2018 | Car, Chi, GB |
| 5 | Chris Doleman+ | 150.5 | 1985-1999 | Min, Atl, SF |
| 6 | Michael Strahan+ | 141.5 | 1993-2007 | NYG |
| 7 | Jason Taylor+ | 139.5 | 1997-2011 | Mia, Was, NYJ |
| 8 | Terrell Suggs | 139.0 | 2003-2019 | Bal, Az, KC |
| 9 | Von Miller | 138.5 | 2011- | Den, LAR, Buf, Was |
| DeMarcus Ware+ | 138.5 | 2005-2016 | Dal, Den | |
| 11 | Richard Dent+ | 137.5 | 1983-1997 | Chi, SF, Ind, Phi |
| John Randle+ | 137.5 | 1990-2003 | Min, Sea | |
| 13 | Jared Allen+ | 136.0 | 2004-2015 | KC, Min, Chi, Car |
| 14 | John Abraham | 133.5 | 2000-2014 | NYJ, Atl, Az |
| 15 | Leslie O’Neal | 132.5 | 1986-1999 | SD, SLR, KC |
| Lawrence Taylor+ | 132.5 | 1981-1993 | NYG | |
| 17 | Cameron Jordan | 132.0 | 2011- | NO |
| 18 | Rickey Jackson+ | 128.0 | 1981-1995 | NO, SF |
| 19 | Derrick Thomas+ | 126.5 | 1989-1999 | KC |
| 20 | Dwight Freeney+ | 125.5 | 2002-2017 | Ind, SD, Az, Atl, Sea, Det |
| Myles Garrett | 125.5 | 2017- | Cle, LAR | |
| 22 | Robert Mathis | 123.0 | 2003-2016 | Ind |
| 23 | Simeon Rice | 122.0 | 1996-2007 | Az, TB, Den, Ind |
| 24 | Clyde Simmons | 121.5 | 1986-2000 | Phi, Az, Jax, Cin, Chi |
| 25 | Calais Campbell | 117.0 | 2008- | Az, Jax, Bal, Atl, Mia |
| 26 | T.J. Watt | 115.0 | 2017- | Pit |
| 27 | Danielle Hunter | 114.5 | 2015- | Min, Hou |
| J.J. Watt | 114.5 | 2011-2022 | Hou, Az | |
| 29 | Sean Jones | 113.0 | 1984-1996 | Raid, Hou, GB |
| Khalil Mack | 113.0 | 2014- | Oak, Chi, LAC | |
| 31 | Justin Houston | 112.0 | 2011-2023 | KC, Ind, Bal, Car, Mia |
| Chandler Jones | 112.0 | 2012-2022 | NE, Az, LV | |
| 33 | Aaron Donald | 111.0 | 2014-2023 | LAR |
| 34 | Greg Townsend | 109.5 | 1983-1997 | Raid, Phi |
| 35 | Pat Swilling | 107.5 | 1986-1998 | NO, Det, Oak |
| 36 | Trace Armstrong | 106.0 | 1989-2003 | Chi, Mia, Oak |
| 37 | Elvis Dumervil | 105.5 | 2006-2017 | Den, Bal, SF |
| 38 | Kevin Carter | 104.5 | 1995-2008 | SLR, Ten, Mia, TB |
| Neil Smith | 104.5 | 1988-2000 | KC, Den, SD | |
| 40 | Jim Jeffcoat | 102.5 | 1983-1997 | Dal, Buf |
| 41 | Robert Quinn | 102.0 | 2011-2022 | LAR, Mia, Dal, Chi, Phi |
| 42 | William Fuller | 100.5 | 1986-1998 | Hou, Phi, SD |
| Charles Haley+ | 100.5 | 1986-1999 | SF, Dal | |
| Cameron Wake | 100.5 | 2009-2019 | Mia, Ten | |
| 45 | Carlos Dunlap | 100.0 | 2010-2022 | Cin, Sea, KC |
| Andre Tippett+ | 100.0 | 1982-1993 | NE | |
| 47 | Joey Porter | 98.0 | 1999-2011 | Pit, Mia, Az |
| 48 | Simon Fletcher | 97.5 | 1985-1995 | Den |
| Jacob Green | 97.5 | 1980-1992 | Sea, SF | |
| Dexter Manley | 97.5 | 1981-1991 | Was, Pho, TB | |
| Mario Williams | 97.5 | 2006-2016 | Hou, Buf, Mia | |
| 52 | Warren Sapp+ | 96.5 | 1995-2007 | TB, Oak |
| 53 | Ryan Kerrigan | 95.5 | 2011-2021 | Was, Phi |
| Robert Porcher | 95.5 | 1992-2003 | Det | |
| 55 | Steve McMichael+ | 95.0 | 1980-1994 | NE, Chi, GB |
| 56 | Jason Pierre-Paul | 94.5 | 2010-2025 | NYG, TB, Bal, NO, Mia |
| 57 | Henry Thomas | 93.5 | 1987-2000 | Min, Det, NE |
| 58 | Cameron Heyward | 92.0 | 2011- | Pit |
| 59 | Clay Matthews | 91.5 | 2009-2019 | GB, LAR |
| 60 | Trevor Pryce | 91.0 | 1997-2010 | Den, Bal, NYJ |
| 61 | Trent Cole | 90.5 | 2005-2016 | Phi, Ind |
| 62 | Tamba Hali | 89.5 | 2006-2017 | KC |
| Bryant Young+ | 89.5 | 1994-2007 | SF | |
| 64 | Ken Harvey | 89.0 | 1988-1998 | Pho, Was |
| 65 | Chris Jones | 87.5 | 2016- | KC |
| Leonard Little | 87.5 | 1998-2009 | SLR | |
| 67 | Justin Smith | 87.0 | 2001-2014 | Cin, SF |
| 68 | Willie McGinest | 86.0 | 1994-2008 | NE, Cle |
| 69 | Everson Griffen | 85.5 | 2010-2021 | Min, Dal, Det |
| 70 | Osi Umenyiora | 85.0 | 2003-2014 | NYG, Atl |
| 71 | James Harrison | 84.5 | 2002-2017 | Pit, Cin, NE |
| 72 | Greg Ellis | 84.0 | 1998-2009 | Dal, Oak |
| Howie Long+ | 84.0 | 1981-1993 | Raid | |
| 74 | La’Roi Glover | 83.5 | 1996-2008 | Oak, NO, Dal, SLR |
| Leonard Marshall | 83.5 | 1983-1994 | NYG, NYJ, Was | |
| 76 | Charles Mann | 83.0 | 1983-1994 | Was, SF |
| 77 | Patrick Kerney | 82.5 | 1999-2009 | Atl, Sea |
| Wayne Martin | 82.5 | 1989-1999 | NO | |
| Lee Williams | 82.5 | 1984-1993 | SD, Hou. Oilers | |
| 80 | Shaun Phillips | 81.5 | 2004-2014 | SD, Den, Ten, Ind |
| 81 | Tim Harris | 81.0 | 1986-1995 | GB, SF, Phi |
| Trey Hendrickson | 81.0 | 2017- | Cin, Bal | |
| 83 | Andre Carter | 80.5 | 2001-2013 | SF, Was, NE, Oak |
| 84 | Hugh Douglas | 80.0 | 1995-2004 | NYJ, Phi, Jax |
| Jason Gildon | 80.0 | 1994-2004 | Pit, Jax | |
| 86 | Brandon Graham | 79.5 | 2010-2025 | Phi |
| 87 | Chad Brown | 79.0 | 1993-2007 | Pit, Sea NE |
| Karl Mecklenburg | 79.0 | 1983-1994 | Den | |
| 89 | Aaron Schobel | 78.0 | 2001-2009 | Buf |
| 90 | Joey Bosa | 77.0 | 2016-2025 | LAC, Buf |
| 91 | Ray Childress | 76.5 | 1985-1996 | Hou, Dal |
| 92 | Geno Atkins | 75.5 | 2010-2020 | Cin |
| 93 | Bryce Paup | 75.0 | 1990-2000 | GB, Buf, Jax, Min |
| 94 | Kabeer Gbaja-Biamila | 74.5 | 2000-2008 | GB |
| 95 | Cliff Avril | 74.0 | 2008-2017 | Det, Sea |
| Mark Gastineau | 74.0 | 1979-1988 | NYJ | |
| Jevon Kearse | 74.0 | 1999-2009 | Ten, Phi | |
| 98 | Shaun Ellis | 73.5 | 2000-2011 | NYJ, NE |
| Michael Sinclair | 73.5 | 1992-2002 | Sea, Phi | |
| 100 | Rob Burnett | 73.0 | 1990-2003 | Cle, Bal, Mia |
