| 1 | Brett Favre+ | 336 | 1991-2010 | Atl, GB, NYJ, Min |
| 2 | George Blanda+ | 277 | 1949-1975 | Chi, Bal.Colts, Hou.Oilers, Oak |
| 3 | John Hadl | 268 | 1962-1977 | LAC, LAR, GB, Hou.Oilers |
| 4 | Vinny Testaverde | 267 | 1987-2007 | TB, Cle, Bal, NYJ, Dal, NE, Car |
| 5 | Fran Tarkenton+ | 266 | 1961-1978 | Min, NYG |
| 6 | Norm Snead | 257 | 1961-1976 | Was, Phi, Min, NYG, SF |
| 7 | Johnny Unitas+ | 253 | 1956-1973 | Bal.Colts, LAC |
| 8 | Dan Marino+ | 252 | 1983-1999 | Mia |
| 9 | Peyton Manning+ | 251 | 1998-2015 | Ind, Den |
| 10 | Y.A. Tittle+ | 248 | 1948-1964 | Bal.Colts AAFC, SF, NYG |
| 11 | Jim Hart | 247 | 1966-1984 | StL.Cardinals, Was |
| 12 | Eli Manning | 244 | 2004-2019 | NYG |
| 13 | Drew Brees | 243 | 2001-2020 | SD, NO |
| | Bobby Layne+ | 243 | 1948-1962 | Chi, NY.Bulldogs, Det, Pit |
| 15 | Dan Fouts+ | 242 | 1973-1987 | SD |
| 16 | Warren Moon+ | 233 | 1984-2000 | Hou.Oilers, Min, Sea, KC |
| 17 | John Elway+ | 226 | 1983-1998 | Den |
| 18 | John Brodie | 224 | 1957-1973 | SF |
| 19 | Ken Stabler+ | 222 | 1970-1984 | Oak, Hou.Oilers, NO |
| 20 | Joe Namath+ | 220 | 1965-1977 | NYJ, LAR |
| | Babe Parilli | 220 | 1952-1969 | GB, Cle, Oak, Bos.Patriots, NYJ |
| 22 | Tom Brady | 212 | 2000-2022 | NE, TB |
| 23 | Ben Roethlisberger | 211 | 2004-2021 | Pit |
| 24 | Terry Bradshaw+ | 210 | 1970-1983 | Pit |
| 25 | Joe Ferguson | 209 | 1973-1990 | Buf, Det, TB, Ind |
| | Philip Rivers | 209 | 2004-2020 | SD, Ind |
| 27 | Steve Grogan | 208 | 1975-1990 | NE |
| 28 | Drew Bledsoe | 206 | 1993-2006 | NE, Buf, Dal |
| 29 | Steve DeBerg | 204 | 1978-1998 | SF, Den, TB, KC, Mia, Atl |
| 30 | Sammy Baugh+ | 203 | 1937-1952 | Was |
| 31 | Dave Krieg | 199 | 1980-1998 | Sea, KC, Det, Az, Chi, Ten |
| 32 | Jim Plunkett | 198 | 1971-1986 | NE, SF, Oak/LA.Raiders |
| 33 | Kerry Collins | 196 | 1995-2011 | Car, NO, NYG, Oak, Ten, Ind |
| 34 | Tobin Rote | 191 | 1950-1966 | GB, Det, SD, Den |
| 35 | Sonny Jurgensen+ | 189 | 1957-1974 | Phi, Was |
| 36 | Matthew Stafford | 188 | 2009-2024 | Det, LAR |
| 37 | Craig Morton | 187 | 1965-1982 | Dal, NYG, Den |
| | Carson Palmer | 187 | 2004-2017 | Cin, Oak, Az |
| 39 | Boomer Esiason | 184 | 1984-1997 | Cin, NYJs, Az |
| 40 | Len Dawson+ | 183 | 1957-1975 | Pit, Cle, Dal.Texans/KC |
| | Jack Kemp | 183 | 1957-1969 | Pit, SD, Buf |
| | Matt Ryan | 183 | 2008-2022 | Atl, Ind |
| 43 | Charley Johnson | 181 | 1961-1975 | LAR, Hou.Oilers, Den |
| 44 | Lynn Dickey | 179 | 1971-1985 | Hou.Oilers, GB |
| 45 | Norm Van Brocklin+ | 178 | 1949-1960 | LAR, Phi |
| 46 | Jim Everett | 175 | 1986-1997 | LAR, NO, SD |
| | Jim Kelly+ | 175 | 1986-1996 | Buf |
| 48 | Archie Manning | 173 | 1971-1984 | NO, Hou.Oilers, Min |
| 49 | Bob Griese+ | 172 | 1967-1980 | Mia |
| 50 | Ryan Fitzpatrick | 169 | 2005-2021 | LAR,Cin,Buf, Ten,Hou,NYJ, TB,Mia,Was |
| 51 | Charlie Conerly | 167 | 1948-1961 | NYG |
| 52 | Jon Kitna | 165 | 1997-2011 | Sea, Cin, Det, Dal |
| 53 | Ron Jaworski | 164 | 1974-1989 | LAR, Phi, Mia, KC |
| 54 | Joe Flacco | 162 | 2008-2024 | Bal, Den, NYJ, Cle, Ind |
| 55 | Dan Pastorini | 161 | 1971-1983 | Hou.Oilers, Oak, LAR, Phi |
| | Jake Plummer | 161 | 1997-2006 | Az, Den |
| | Richard Todd | 161 | 1976-1985 | NYJ, NO |
| 58 | Ken Anderson | 160 | 1971-1986 | Cin |
| | Jay Cutler | 160 | 2006-2017 | Den, Chi, Mia |
| 60 | Tommy Kramer | 158 | 1977-1990 | Min, NO |
| 61 | Phil Simms | 157 | 1979-1993 | NYG |
| 62 | Matt Hasselbeck | 153 | 1999-2015 | GB, Sea, Ten, Ind |
| 63 | Andy Dalton | 150 | 2011-2024 | Cin, Dal, Chi, NO, Car |
