| No. | Quarterback | TD | Periodo | Equipo(s) |
|---|---|---|---|---|
| 1 | Tom Brady | 649 | 2000-2022 | (2) NE, TB |
| 2 | Drew Brees+ | 571 | 2001-2020 | (2) SD, NO |
| 3 | Peyton Manning+ | 539 | 1998-2015 | (2) Ind, Den |
| 4 | Aaron Rodgers | 527 | 2005- | (3) GB, NYJ, Pit |
| 5 | Brett Favre+ | 508 | 1991-2010 | (4) Atl, GB, NYJ, Min |
| 6 | Philip Rivers | 425 | 2004-2025 | (2) SD/LAC, Ind |
| 7 | Matthew Stafford | 423 | 2009- | (2) Det, LAR |
| 8 | Dan Marino+ | 420 | 1983-1999 | (1) Mia |
| 9 | Ben Roethlisberger | 418 | 2004-2021 | (1) Pit |
| 10 | Matt Ryan | 381 | 2008-2022 | (2) Atl, Ind |
| 11 | Eli Manning | 366 | 2004-2019 | (1) NYG |
| 12 | Russell Wilson | 353 | 2012-2025 | (4) Sea, Den, Pit, NYG |
| 13 | Fran Tarkenton+ | 342 | 1961-1978 | (2) NYG, Min |
| 14 | John Elway+ | 300 | 1983-1998 | (1) Den |
| 15 | Kirk Cousins | 298 | 2012- | (4) Was, Min, Atl, LV |
| 16 | Carson Palmer | 294 | 2004-2017 | (3) Cin, Az, Oak |
| 17 | Warren Moon+ | 291 | 1984-2000 | (4) Hou.Oilers, Min, KC, Sea |
| 18 | Johnny Unitas+ | 290 | 1956-1973 | (2) Bal.Colts, SD |
| 19 | Vinny Testaverde | 275 | 1987-2007 | (7) TB, Cle, Bal, NYJ, Dal, NE, Car |
| 20 | Joe Montana+ | 273 | 1979-1994 | (2) SF, KC |
| 21 | Joe Flacco | 271 | 2008- | (5) Bal, Den, NYJ, Cle, Ind |
| 22 | Patrick Mahomes | 267 | 2017- | (1) KC |
| 23 | Dave Krieg | 261 | 1980-1998 | (6) Sea, KC, Det, Az, Chi, Ten |
| 24 | Derek Carr | 257 | 2014-2024 | (2) Oak/LVR, NO |
| 25 | Jared Goff | 256 | 2016- | (2) LAR, Det |
| 26 | Sonny Jurgensen+ | 255 | 1957-1974 | (2) Was, Phi |
| 27 | Dan Fouts+ | 254 | 1973-1987 | (1) SD |
| Andy Dalton | 254 | 2011- | (5) Cin, Dal, Chi, NO, Car | |
| 29 | Drew Bledsoe | 251 | 1993-2006 | (3) NE, Buf, Dal |
| 30 | Tony Romo | 248 | 2004-2016 | (1) Dal |
| 31 | Boomer Esiason | 247 | 1984-1997 | (3) Cin, NYJ, Az |
| 32 | John Hadl | 244 | 1962-1977 | (4) SD, LAR, GB, Hou |
| 33 | Dak Prescott | 243 | 2016- | (1) Dal |
| 34 | Y.A. Tittle+ | 242 | 1948-1964 | (3) Bal.Colts AAFC, SF, NYG |
| 35 | Len Dawson+ | 239 | 1957-1975 | (3) Pit, Cle, Dal.Texans/KC |
| 36 | Jim Kelly+ | 237 | 1986-1996 | (1) Buf |
| 37 | George Blanda+ | 236 | 1949-1975 | (4) Chi, Bal, Hou.Oilers, Oak |
| 38 | Donovan McNabb | 234 | 1999-2011 | (3) Phi, Was, Min |
| 39 | Steve Young+ | 232 | 1995-1999 | (2) TB, SF |
| 40 | Jay Cutler | 227 | 2006-2017 | (3) Chi, Den, Mia |
| 41 | Ryan Fitzpatrick | 223 | 2005-2021 | (9) LAR,Cin,Buf,Ten,Hou, NYJ,TB,Mia,Was |
| 42 | Josh Allen | 220 | 2018- | (1) Buf |
| 43 | Ryan Tannheill | 216 | 2012-2023 | (2) Mia, Ten |
| 44 | John Brodie | 214 | 1957-1973 | (1) SF |
| 45 | Terry Bradshaw+ | 212 | 1970-1983 | (1) Pit |
| Matt Hasselbeck | 212 | 1999-2015 | (4) GB, Sea, Ten, Ind | |
| 47 | Jim Hart | 209 | 1966-1984 | (2) StL.Card., Was |
| 48 | Kerry Collins | 208 | 1995-2011 | (6) Car, NYG, |
| Kurt Warner+ | 208 | 1998-2009 | (3) LAR, NYG, Az | |
| 50 | Randall Cunningham | 207 | 1985-2001 | (4) Phi, Min, Dal, |
| 51 | Jim Everett | 203 | 1986-1997 | (3) LAR, NO, SD |
| 52 | Roman Gabriel | 201 | 1962-1977 | (2) LAR, Phi |
De 200 pases de touchdown en adelante.