| 1 | Evanivaldo Castro | 312 | 289 | 23 | 1974-87 | UNAM (151), Atlante (108), León (44), Tigres UANL (9) |
| 2 | Carlos Hermosillo | 294 | 269 | 25 | 1984-2001 | América (78), Monterrey (20), Cruz Azul (169), Necaxa (13), Atlante (7), Guadalajara (7) |
| 3 | Jared Borgetti | 252 | 212 | 40 | 1994-2005 y 2007-10 | Atlas (21), Santos (189), Sinaloa (8), Pachuca (8), Cruz Azul (7), Monterrey (10), Puebla (5), Morelia (4) |
| 4 | José Saturnino Cardozo | 249 | 206 | 43 | 1994-2005 | Toluca (249) |
| 5 | Horacio Casarín | 238 | 238 | | 1936-57 | Atlante (107), Zacatepec (24), España (21), Necaxa (70), América (13), Monterrey (3) |
| 6 | Osvaldo Castro | 214 | 210 | 4 | 1971-84 | América (45), Jalisco (91), Neza (45), Atlético Potosino (24), UNAM (9) |
| 7 | Luis Roberto Alves | 209 | 184 | 25 | 1986-2003 | América (162), Atlante (24), Necaxa (23) |
| 8 | Adalberto López | 201 | 201 | | 1942-55 | Atlante (10), León (126), Atlas (14), Oro (27), Guadalajara (24) |
| 9 | Carlos Eloir Perucci | 199 | 192 | 7 | 1972-84 | Laguna (64), Atlético Español (86), Cruz Azul (47) |
| 10 | Sergio Lira | 191 | 182 | 9 | 1978-96 | Tampico (36), Atlante (2), Oaxtepec (20), Tampico Madero (102), Tigres (18), Puebla (13) |
| 11 | Ricardo Peláez | 187 | 170 | 17 | 1985-2000 | América (33), Necaxa (138), Guadalajara (16) |
| 12 | Ricardo Ferretti | 182 | 175 | 7 | 1977-91 | Atlas (9), UNAM (116), Neza (6), Monterrey (9), Toluca (43) |
| 13 | Horacio López Salgado | 172 | 160 | 12 | 1967-80 | América (39), Cruz Azul (133) |
| 14 | Ricardo Brandon | 172 | 159 | 13 | 1971-83 | Atlético Español (55), Veracruz (45), Toluca (33), Atlético Potosino (15), Atletas Campesinos (12), Oaxtepec (9) |
| 15 | Enrique Borja | 168 | 166 | 2 | 1964-77 | UNAM (69), América (99) |
| 16 | Oribe Peralta | 166 | 146 | 20 | 2004-21 | Monterrey (11), Santos (82), Jaguares (12), América (60), Guadalajara (1) |
| 17 | Daniel Guzmán | 158 | 141 | 17 | 1984-98 | U de G (53), Atlante (41), Santos (17), Guadalajara (19), Puebla (12), Atlas (16) |
| 18 | Luis García | 158 | 138 | 20 | 1987-2000 | UNAM (76), América (39), Atlante (14), Guadalajara (20), Morelia (9) |
| 19 | Luis Gabriel Rey | 156 | 139 | 17 | 2003-17 | Atlante (53), Morelia (43), Pachuca (5), Jaguares (33), América (10), Puebla (12) |
| 20 | Alberto García-Aspe | 152 | 124 | 28 | 1984-2002 | UNAM (41), Necaxa (71), América (11), Puebla (29) |
| 21 | Omar Bravo | 151 | 140 | 11 | 2001-16 | Guadalajara (132), Cruz Azul (6), Atlas (13) |
| 22 | Benjamín Galindo | 150 | 130 | 20 | 1979-2001 | Tampico (3), Tampico Madero (23), Guadalajara (78), Santos (24), Cruz Azul (19), Pachuca (3) |
| 23 | José de Jesús Aceves | 148 | 139 | 9 | 1974-90 | Atlas (82), América (18), Atlante (13) Tampico (5), UAG (17), Tigres (13) |
| 24 | Cuauhtémoc Blanco | 147 | 132 | 15 | 1992-2000, 2002-08, 2014-15, 16 | América (125), Necaxa (13), Veracruz (5), Santos (1), Puebla (3) |
| 25 | Alfredo Moreno | 146 | 144 | 2 | 2001-15 | Necaxa (58), San Luis (51), América (4), Atlas (11), Tijuana (16), Puebla (3), Veracruz (3) |
| 26 | Matías Vuoso | 145 | 133 | 12 | 2003-16 | Santos (94), América (27), Atlas (10), Chiapas (9), Cruz Azul (5) |
| 27 | André-Pierre Gignac | 143 | 117 | 26 | 2015- | Tigres UANL (143) |
| 28 | Miguel Sabah | 139 | 125 | 14 | 2000-16 | Guadalajara (21), Cruz Azul (42), Morelia (64), León (12) |
| 29 | Marco Antonio Figueroa | 138 | 129 | 9 | 1986-91, 1993-98 | Morelia (130), América (5), Celaya (3) |
| 30 | Luis Pirata Fuente | 136 | 136 | | 1933-50 | Aurrera, España, América, Marte, Veracruz |
| 31 | Mario Pérez | 135 | 135 | | 1945-56 | Marte (105) y Zacatepec (30) |
| 32 | Hugo Kiese | 135 | 133 | 2 | 1975-87 | Tecos UAG (115), América (20), Atlas (0) |
| 33 | Carlos Poblete | 132 | 116 | 16 | 1986-96 | Puebla (83), Ángeles de Puebla (20), Cruz Azul (14), Veracruz (15) |
| 34 | Héctor Hernández | 130 | 130 | | 1953-69 | Oro (68), Guadalajara (48), Nuevo León (14) |
| 35 | Luis Flores | 127 | 117 | 10 | 1980-95 | UNAM (95), Cruz Azul (20), Atlas (12), Guadalajara (0) |
| 36 | Carlos Lara | 127 | 127 | | 1956-62 y 1963-69 | Zacatepec (112), Toluca (6), Necaxa (9) |
| 37 | Alberto Mendoza | 126 | 126 | | 1939-47 | Atlante, Asturias, Marte, León, San Sebastián, Veracruz, Puebla |
| 38 | Salvador Cabañas | 125 | 117 | 8 | 2003-10 | Jaguares (59), América (66) |
| 39 | Salvador Reyes | 125 | 125 | | 1953-67, 1968-71 | Guadalajara (122), San Luis (3) |
| 40 | Jaime Belmonte | 125 | 125 | | 1956-72 | Cuautla (19), Irapuato (106) |
| 41 | Héctor Mancilla | 125 | 113 | 12 | 2006-16 | Veracruz (15), Toluca (55), Tigres (24), Atlas (6), Morelia (23), Dorados de Sinaloa (2) |
| 42 | Isidro Lángara | 124 | 124 | | 1938-39, 1943-46 | Euskadi (19), España (105) |
| 43 | Alfredo Jiménez | 124 | 119 | 5 | 1970-81 | Monterrey (53), Toluca (6), Tigres (40), Cruz Azul (25) |
| 44 | Emanuel Villa | 124 | 121 | 3 | 2006-17 | Atlas (15), UAG (13), Cruz Azul (54), UNAM (3), Tigres (11), Querétaro (28) |
| 45 | Octavio Vial | 123 | 123 | | 1937-49 | América (123) |
| 46 | Hugo Sánchez | 123 | 114 | 9 | 1976-81, 1992-93, 1994-95 y 97 | UNAM (97), América (11), Atlante (13), Celaya (2) |
| 47 | Francisco Palencia | 121 | 108 | 13 | 1994-2011 | Cruz Azul (89), Guadalajara (13), UNAM (19) |
| 48 | Jesús Olalde | 119 | 112 | 7 | 1993-2006 | UNAM (81), Tigres (35), Atlante (3) |
| 49 | Vicente Pereda | 119 | 119 | | 1960-76 | Toluca (119) |
| 50 | Carlos María Morales | 118 | 102 | 16 | 1995-2005 | Toluca (77), Atlas (33), Tecos UAG (8) |
| 51 | Rodrigo Ruiz | 118 | 106 | 12 | 1994-2012 | Puebla (10), Toros Neza (32), Santos (59), Veracruz (2), Estudiantes Tecos (15) |
| 52 | Claudio Da Silva | 117 | 109 | 8 | 1997-2004 | Morelia (47), Monterrey (9), Pachuca (14), Puebla (10), Celaya (7), Colibríes (8) |
| 53 | Amaury Epaminondas | 117 | 117 | | 1962-68 | Oro (68), Toluca (49) |
| 54 | Sebastián Abreu | 116 | 110 | 6 | 1999-2000, 2002-04, 2005-07 | UAG (34), Cruz Azul (37), América (3), Dorados de Sinaloa (22), Monterrey (8), San Luis (5), Tigres (7) |
| 55 | Tomás Boy | 116 | 108 | 8 | 1970-88 | Atlético Español (12), Atlético Potosino (6), Tigres (98) |
| 56 | Christian Giménez | 116 | 102 | 14 | 2004-18 | Veracruz (4), América (5), Pachuca (45), Cruz Azul (62) |
| 57 | Luis Estrada | 115 | 113 | 2 | 1964-78 | León (90), Cruz Azul (25) |
| 58 | Agustín Manzo | 114 | 112 | 2 | 1976-90 | América (17), Puebla (2), Toluca (45), Cruz Azul (47), Tampico Madero (3) |
| 59 | Juan Pablo Rodríguez | 114 | 98 | 16 | 1997-2018 | Atlas (54), Estudiantes (12), Santos (36), Morelia (12) |
| 60 | Ricardo Álvarez | 113 | 113 | | 1944-51 | Moctezuma (17), Puebla (87), Veracruz (9) |
| 61 | Walter Meneses | 113 | 113 | | 1944-56 | Puebla (19), Moctezuma (27), ADO (30), Asturias (12), Marte (6), Atlante (7), Oro (18) |
| 62 | Rubén Romeo Corbo | 112 | 106 | 6 | 1974-84 | Monterrey (64), Tampico (24), Tampico Madero (23) |
| 63 | Mariano Ubiracy | 111 | 111 | | 1965-75 | Veracruz (98) Jalisco (7), Irapuato (6) |
| 64 | Luis Miguel Salvador | 111 | 107 | 4 | 1989-2000 | Atlante (78), Monterrey (21), Celaya (12) |
| 65 | Rafael Márquez Lugo | 110 | 99 | 11 | 2000-15 | UNAM (8), Jaguares (3), Morelia (58), Pachuca (2), Estudiantes (2), América (2), Atlante (14), Guadalajara (20) |
| 66 | Rubén Omar Romano | 110 | 106 | 4 | 1979-95 | América (3), León (24), Necaxa (18), Puebla (17), Atlante (27), Querétaro (9), Cruz Azul (8), Veracruz (4) |
| 67 | Luis Hernández | 108 | 101 | 7 | 1990-2004 | Cruz Azul (1), Monterrey (15), Necaxa (37), Tigres (39), América (10), Veracruz (5), Jaguares (1) |
| 68 | Manuel Negrete | 108 | 97 | 11 | 1976-86 y 1987-96 | UNAM (102), Monterrey (0), Atlante (3), Toros Neza (3) |
| 69 | Rogelio Funes Mori | 107 | 92 | 15 | 2015- | Monterrey (107) |
| 70 | Pablo González | 106 | 106 | | 1940-50 | Selección Jalisco, Guadalajara, Oro |
| 71 | Juan Carlos Cacho | 105 | 97 | 8 | 2001-14 | Cruz Azul (22), Pachuca (53), UNAM (24), Toluca (6) |
| 72 | José Manuel Abundis | 105 | 93 | 12 | 1992-2007 | Toluca (80), Atlante (23), Monterrey (1), Pachuca (0), Querétaro (1) |
| 73 | Alberto Etcheverry | 105 | 105 | | 1958-69 | León (33), Irapuato (22), UNAM (27), Atlante (9), Nuevo León (14) |
| 74 | Mauro Boselli | 105 | 94 | 11 | 2013-18 | León (105) |
| 75 | Ernesto Candia | 104 | 104 | | 1943-58 | Moctezuma (10), Tampico (65), Zacatepec (29) |
| 76 | Daniel Ludueña | 104 | 89 | 15 | 2005-16 | UAG (30), Santos Laguna (63), Pachuca (2), UNAM (9) |
| 77 | Adolfo Bautista | 104 | 85 | 19 | 1998-2011 | UAG (15), Morelia (19), Pachuca (2), Guadalajara (45), Chiapas (22), Querétaro (1) |
| 78 | Silvio Fogel | 103 | 103 | | 1975-83 | Puebla (84), Torreón (12), América (5), Cruz Azul (1) |
| 79 | Christian Benítez | 103 | 92 | 11 | 2007-09, 2010-13 | Santos (51), América (52) |
| 80 | Julio Ayllón | 102 | 102 | | 1946-54 | Moctezuma (42), Veracruz (30), León (10), Tampico (20) |
| 81 | Julio María Palleiro | 102 | 102 | | 1951-61 | Necaxa (64), Toluca (24), América (7) |
| 82 | Eladio Vera | 102 | 95 | 7 | 1971-79 | Cruz Azul (77), UAG (25) |
| 83 | Humberto Suazo | 102 | 85 | 17 | 2007-14 | Monterrey (102) |
| 84 | Ivo Basay | 101 | 95 | 6 | 1990-95 | Necaxa (101) |
| 85 | Alex Fernandes | 101 | 91 | 10 | 1999-2007 | Morelia (70), Monterrey (31) |
| 86 | Mario Hernández | 101 | 86 | 15 | 1978-90 | Zacatepec (56), Atlante (20), Puebla (6), Ángeles de Puebla (9), Tampico Madero (8), Tigres (2) |
