| No. | Quarterback | Equipo | Intercepciones | Temporada |
|---|---|---|---|---|
| 1 | George Blanda | Oilers | 42 | 1962 |
| 2 | Vinny Testaverde | Buccaneers | 35 | 1988 |
| 3 | Frank Tripucka | Broncos | 34 | 1960 |
| 4 | John Hadl | Chargers | 32 | 1968 |
| Fran Tarkenton | Vikings | 32 | 1978 | |
| 6 | Sid Luckman | Bears | 31 | 1947 |
| 7 | George Blanda | Oilers | 30 | 1965 |
| Al Dorow | NY Titans | 30 | 1961 | |
| Jim Hart | Cardinals | 30 | 1967 | |
| Ken Stabler | Raiders | 30 | 1978 | |
| Richard Todd | Jets | 30 | 1980 | |
| Jameis Winston | Buccaneers | 30 | 2019 | |
| 13 | Lynn Dickey | Packers | 29 | 1983 |
| Brett Favre | Packers | 29 | 2005 | |
| 15 | Peyton Manning | Colts | 28 | 1998 |
| Joe Namath | Jets | 28 | 1967 | |
| Joe Namath | Jets | 28 | 1975 | |
| Ken Stabler | Oilers | 28 | 1980 | |
| Y.A. Tittle | 49ers | 28 | 1955 | |
| 20 | George Blanda | Oilers | 27 | 1964 |
| Drew Bledsoe | Patriots | 27 | 1994 | |
| Eli Manning | Giants | 27 | 2013 | |
| Joe Namath | Jets | 27 | 1966 | |
| Babe Parilli | AFL, Boston Patriots | 27 | 1964 | |
| Bud Schwenk | Chicago Cardinals | 27 | 1942 | |
| Norm Snead | Redskins | 27 | 1963 | |
| Jim Zorn | Seahawks | 27 | 1976 | |
| 28 | Jay Cutler | Bears | 26 | 2009 |
| Al Dorow | AFL, NY Titans | 26 | 1960 | |
| Jim Finks | Steelers | 26 | 1955 | |
| John Hadl | Chargers | 26 | 1972 | |
| Sonny Jurgensen | Eagles | 26 | 1962 | |
| Jack Kemp | Bills | 26 | 1964 | |
| Jack Kemp | Bills | 26 | 1967 | |
| Tommy Kramer | Vikings | 26 | 1985 | |
| Warren Moon | Oilers | 26 | 1986 | |
| Babe Parilli | Patriots | 26 | 1965 | |
| Dennis Shaw | Bills | 26 | 1971 | |
| Brian Sipe | Browns | 26 | 1979 | |
| Richard Todd | Jets | 26 | 1983 | |
| 41 | George Blanda | Oilers | 25 | 1963 |
| Terry Bradshaw | Steelers | 25 | 1979 | |
| Charlie Conerly | Giants | 25 | 1953 | |
| Lynn Dickey | Packers | 25 | 1980 | |
| Joe Ferguson | Bills | 25 | 1983 | |
| Frank Filchock | Giants | 25 | 1946 | |
| John Hadl | Chargers | 25 | 1971 | |
| Bobby Hebert | Falcons | 25 | 1996 | |
| Jack Kemp | Chargers | 25 | 1960 | |
| Daryle Lamonica | Raiders | 25 | 1969 | |
| Eddie LeBaron | Cowboys | 25 | 1960 | |
| Eli Manning | Giants | 25 | 2010 | |
| Jim Plunkett | Patriots | 25 | 1972 | |
| Brian Sipe | Browns | 25 | 1981 | |
| Fran Tarkenton | Vikings | 25 | 1962 | |
| Vinny Testaverde | Jets | 25 | 2000 | |
| Frank Tripucka | Broncos | 25 | 1962 | |
| Danny White | Cowboys | 25 | 1980 | |
| Dick Wood | Jets | 25 | 1964 | |
| 60 | Terry Bradshaw | Steelers | 24 | 1970 |
| John Brodie | 49ers | 24 | 1971 | |
| Brett Favre | Packers | 24 | 1993 | |
| Joe Ferguson | Bills | 24 | 1977 | |
| Dan Fouts | Chargers | 24 | 1979 | |
| Dan Fouts | Chargers | 24 | 1980 | |
| Otto Graham | Browns | 24 | 1952 | |
| Trent Green | Chiefs | 24 | 2001 | |
| John Hadl | Chargers | 24 | 1962 | |
| Jim Hardy | Cardinals | 24 | 1950 | |
| Charley Johnson | Cardinals | 24 | 1964 | |
| Sonny Jurgensen | Eagles | 24 | 1961 | |
| Tommy Kramer | Vikings | 24 | 1979 | |
| Tommy Kramer | Vikings | 24 | 1981 | |
| Dave Krieg | Seahawks | 24 | 1984 | |
| Babe Parilli | AFL, Boston Patriots | 24 | 1963 | |
| Babe Parilli | AFL, Boston Patriots | 24 | 1967 | |
| Jake Plummer | Cardinals | 24 | 1999 | |
| George Ratterman | NY Yanks | 24 | 1950 | |
| Tobin Rote | Packers | 24 | 1950 | |
| Norm Snead | Eagles | 24 | 1967 | |
| Ken Stabler | Raiders | 24 | 1975 | |
| Johnny Unitas | Colts | 24 | 1960 | |
| Johnny Unitas | Colts | 24 | 1961 | |
| Johnny Unitas | Colts | 24 | 1966 | |
| Billy Wade | Bears | 24 | 1962 | |
| Bob Waterfield | Rams | 24 | 1949 | |
| Doug Williams | Buccaneers | 24 | 1979 | |
| 88 | Frankie Albert | 49ers | 23 | 1950 |
| Steve Bartkowski | Falcons | 23 | 1981 | |
| Sammy Baugh | Redskins | 23 | 1948 | |
| George Blanda | Bears | 23 | 1953 | |
| Adrian Burk | Eagles | 23 | 1951 | |
| Daunte Culpepper | Vikings | 23 | 2002 | |
| Cotton Davidson | AFL, Dallas Texans | 23 | 1961 | |
| Cotton Davidson | AFL, Dallas Texans/Raiders | 23 | 1962 | |
| John Elway | Broncos | 23 | 1985 | |
| Brett Favre | Packers | 23 | 1998 | |
| Brett Favre | Packers | 23 | 1999 | |
| Vince Ferragamo | Rams | 23 | 1983 | |
| Ryan Fitzpatrick | Bills | 23 | 2011 | |
| Steve Grogan | Patriots | 23 | 1978 | |
| Jeff Komlo | Lions | 23 | 1979 | |
| Tommy Kramer | Vikings | 23 | 1980 | |
| Bobby Layne | Lions | 23 | 1951 | |
| Peyton Manning | Colts | 23 | 2001 | |
| Dan Marino | Dolphins | 23 | 1986 | |
| Dan Marino | Dolphins | 23 | 1988 | |
| Paul McDonald | Browns | 23 | 1984 | |
| Bill Nelsen | Browns | 23 | 1971 | |
| Joe Pisarcik | Giants | 23 | 1978 | |
| Ben Roethlisberger | Steelers | 23 | 2006 | |
| Brian Sipe | Browns | 23 | 1983 | |
| Norm Snead | Eagles | 23 | 1969 | |
| Johnny Unitas | Colts | 23 | 1962 | |
| Danny White | Cowboys | 23 | 1983 | |
| Randy Wright | Packers | 23 | 1986 | |
| 117 | Ken Anderson | Bengals | 22 | 1978 |
| George Blanda | Oilers | 22 | 1960 | |
| George Blanda | Oilers | 22 | 1961 | |
| Terry Bradshaw | Steelers | 22 | 1971 | |
| Terry Bradshaw | Steelers | 22 | 1980 | |
| Drew Brees | Saints | 22 | 2010 | |
| John Brodie | 49ers | 22 | 1966 | |
| Aaron Brooks | Saints | 22 | 2001 | |
| Scott Brunner | Giants | 22 | 1983 | |
| Marc Bulger | Rams | 22 | 2003 | |
| Paul Christman | Cardinals | 22 | 1947 | |
| Charlie Conerly | Giants | 22 | 1951 | |
| Steve DeBerg | 49ers | 22 | 1978 | |
| Boomer Esiason | Bengals | 22 | 1990 | |
| Brett Favre | Jets | 22 | 2008 | |
| Joe Flacco | Ravens | 22 | 2013 | |
| Dan Fouts | Chargers | 22 | 1986 | |
| Josh Freeman | Buccaneers | 22 | 2011 | |
| Paul Governali | Boston Yanks/Giants | 22 | 1947 | |
| Steve Grogan | Patriots | 22 | 1980 | |
| John Hadl | Chargers | 22 | 1967 | |
| Joey Harrington | Lions | 22 | 2003 | |
| George Herring | Broncos | 22 | 1961 | |
| Jack Kemp | Chargers | 22 | 1961 | |
| Jack Kemp | Bills | 22 | 1969 | |
| Jon Kitna | Bengals | 22 | 2001 | |
| Jon Kitna | Lions | 22 | 2006 | |
| DeShone Kizer | Browns | 22 | 2017 | |
| Johnny Lujack | Bears | 22 | 1949 | |
| Dan Marino | Dolphins | 22 | 1989 | |
| Lamar McHan | Cardinals | 22 | 1954 | |
| Joe Namath | Jets | 22 | 1974 | |
| Carson Palmer | Cardinals | 22 | 2013 | |
| Jim Plunkett | Patriots | 22 | 1974 | |
| George Ratterman | Bills | 22 | 1948 | |
| Jay Schroeder | Redskins | 22 | 1986 | |
| Phil Simms | Giants | 22 | 1986 | |
| Norm Snead | Redskins | 22 | 1961 | |
| Norm Snead | Redskins | 22 | 1962 | |
| Norm Snead | Giants | 22 | 1973 | |
| Ken Stabler | Raiders | 22 | 1979 | |
| Vinny Testaverde | Buccaneers | 22 | 1989 | |
| Tommy Thompson | Eagles | 22 | 1950 | |
| Y.A. Tittle | Giants | 22 | 1964 | |
| Richard Todd | Jets | 22 | 1979 | |
| Billy Wade | Rams | 22 | 1958 | |
| Kurt Warner | Rams | 22 | 2001 | |
| 164 | Pete Beathard | Oilers | 21 | 1969 |
| George Blanda | Oilers | 21 | 1966 | |
| Drew Bledsoe | Patriots | 21 | 1999 | |
| Zeke Bratkowski | Bears | 21 | 1960 | |
| John Brodie | 49ers | 21 | 1968 | |
| Rudy Bukich | Bears | 21 | 1966 | |
| Ronnie Cahill | Cardinals | 21 | 1943 | |
| Quincy Carter | Cowboys | 21 | 2003 | |
| Kerry Collins | Panthers | 21 | 1997 | |
| Irv Comp | Packers | 21 | 1944 | |
| Tim Couch | Browns | 21 | 2001 | |
| Steve DeBerg | 49ers | 21 | 1979 | |
| Craig Erickson | Buccaneers | 21 | 1993 | |
| Brett Favre | Packers | 21 | 2003 | |
| John Grigas | Cardinals | 21 | 1944 | |
| Steve Grogan | Patriots | 21 | 1977 | |
| John Hadl | Chargers | 21 | 1965 | |
| John Hadl | Packers | 21 | 1975 | |
| Sam Howell | Commanders | 21 | 2023 | |
| Jack Jacobs | Packers | 21 | 1948 | |
| Ron Jaworski | Eagles | 21 | 1977 | |
| Brad Johnson | Buccaneeres | 21 | 2003 | |
| Charley Johnson | Cardinals | 21 | 1963 | |
| Randy Johnson | Falcons | 21 | 1966 | |
| Randy Johnson | Falcons | 21 | 1967 | |
| Bert Jones | Colts | 21 | 1980 | |
| Dave Krieg | Cardinals | 21 | 1995 | |
| Bobby Layne | Lions | 21 | 1953 | |
| Bobby Layne | Steelers | 21 | 1959 | |
| Johnny Lujack | Bears | 21 | 1950 | |
| Archie Manning | Saints | 21 | 1972 | |
| Dan Marino | Dolphins | 21 | 1985 | |
| Baker Mayfield | Browns | 21 | 2019 | |
| Hugh McCullough | Cardinals | 21 | 1940 | |
| Warren Moon | Oilers | 21 | 1991 | |
| Warren Moon | Oilers | 21 | 1993 | |
| Craig Morton | Cowboys | 21 | 1972 | |
| Joe Namath | Jets | 21 | 1972 | |
| Dan Pastorini | Oilers | 21 | 1971 | |
| Jake Plummer | Cardinals | 21 | 2000 | |
| Philip Rivers | Chargers | 21 | 2016 | |
| Geno Smith | Jets | 21 | 2013 | |
| Norm Snead | Eagles | 21 | 1968 | |
| Cliff Stoudt | Steelers | 21 | 1983 | |
| Fran Tarkenton | Giants | 21 | 1971 | |
| Bobby Thomason | Eagles | 21 | 1956 | |
| Jack Thompson | Buccaneers | 21 | 1983 | |
| Frank Tripucka | Broncos | 21 | 1961 | |
| Bill Troup | Colts | 21 | 1978 | |
| Norm Van Brocklin | Rams | 21 | 1954 | |
| Norm Van Brocklin | Rams | 21 | 1957 | |
| Marc Wilson | Raiders | 21 | 1985 | |
| 216 | Steve Bartkowski | Falcons | 20 | 1979 |
| Terry Bradshaw | Steelers | 20 | 1978 | |
| Dave Brown | Giants | 20 | 1996 | |
| Ed Brown | Steelers | 20 | 1963 | |
| Mark Brunell | Jaguars | 20 | 1996 | |
| Kerry Collins | Raiders | 20 | 2004 | |
| Charlie Conerly | Giants | 20 | 1949 | |
| Andy Dalton | Bengals | 20 | 2013 | |
| Glenn Dobbs | LA Dons | 20 | 1948 | |
| Vince Evans | Bears | 20 | 1981 | |
| Jim Everett | Rams | 20 | 1991 | |
| Joe Ferguson | Bills | 20 | 1981 | |
| Dan Fouts | Chargers | 20 | 1978 | |
| Dan Fouts | Chargers | 20 | 1985 | |
| Johnny Gildea | Steelers | 20 | 1935 | |
| Otto Graham | Browns | 20 | 1950 | |
| Steve Grogan | Patriots | 20 | 1976 | |
| Steve Grogan | Patriots | 20 | 1979 | |
| Rex Grossman | Bears | 20 | 2006 | |
| Rex Grossman | Redskins | 20 | 2011 | |
| Jim Hart | Cardinals | 20 | 1977 | |
| Jim Hart | Cardinals | 20 | 1979 | |
| Jim Hart | Cardinals | 20 | 1980 | |
| Ron Jaworski | Eagles | 20 | 1981 | |
| Ron Jaworski | Eagles | 20 | 1985 | |
| Charley Johnson | Cardinals | 20 | 1962 | |
| Bert Jones | Colts | 20 | 1981 | |
| Jack Kemp | Bills | 20 | 1963 | |
| Jon Kitna | Lions | 20 | 2007 | |
| Dave Krieg | Seahawks | 20 | 1985 | |
| Dave Krieg | Seahawks | 20 | 1989 | |
| Dave Krieg | Seahawks | 20 | 1990 | |
| Daryle Lamonica | Raiders | 20 | 1967 | |
| Bobby Layne | Lions | 20 | 1952 | |
| Jacky Lee | Broncos | 20 | 1964 | |
| Clyde LeForce | Lions | 20 | 1947 | |
| Chuck Long | Lions | 20 | 1987 | |
| Don Majkowski | Packers | 20 | 1989 | |
| Archie Manning | Saints | 20 | 1975 | |
| Archie Manning | Saints | 20 | 1979 | |
| Archie Manning | Saints | 20 | 1980 | |
| Eli Manning | Giants | 20 | 2007 | |
| Rick Mirer | Seahawks | 20 | 1995 | |
| Craig Morton | Giants | 20 | 1976 | |
| Ken O’Brien | Jets | 20 | 1986 | |
| Carson Palmer | Bengals | 20 | 2007 | |
| Carson Palmer | Bengals | 20 | 2010 | |
| Babe Parilli | Boston Patriots | 20 | 1966 | |
| Mike Phipps | Browns | 20 | 1973 | |
| Jake Plummer | Cardinals | 20 | 1998 | |
| Jake Plummer | Cardinals | 20 | 2002 | |
| Jake Plummer | Broncos | 20 | 2004 | |
| Milt Plum | Lions | 20 | 1962 | |
| George Ratterman | Bills | 20 | 1947 | |
| Philip Rivers | Chargers | 20 | 2011 | |
| Philip Rivers | Chargers | 20 | 2019 | |
| Tobin Rote | Packers | 20 | 1951 | |
| Mark Sanchez | Jets | 20 | 2009 | |
| Bud Schwenk | Colts | 20 | 1947 | |
| Dennis Shaw | Bills | 20 | 1970 | |
| Phil Simms | Giants | 20 | 1985 | |
| Frankie Sinkwich | Lions | 20 | 1943 | |
| Frankie Sinkwich | Lions | 20 | 1944 | |
| Norm Snead | Eagles | 20 | 1970 | |
| Ken Stabler | Raiders | 20 | 1977 | |
| Matthew Stafford | Lions | 20 | 2009 | |
| Vinny Testaverde | Cowboys | 20 | 2004 | |
| Joe Theismann | Redskins | 20 | 1981 | |
| Bobby Thomason | Eagles | 20 | 1953 | |
| Y.A. Tittle | Giants | 20 | 1962 | |
| Johnny Unitas | Colts | 20 | 1969 | |
| Norm Van Brocklin | Eagles | 20 | 1958 | |
| Jim Zorn | Seahawks | 20 | 1978 | |
| Jim Zorn | Seahawks | 20 | 1980 |
