| 1 | Lionel Messi | 474 | 520 | F. C. Barcelona (474) |
| 2 | Cristiano Ronaldo | 311 | 292 | Real Madrid C. F. (311) |
| 3 | Telmo Zarra | 251 | 277 | Athletic Club (251) |
| 4 | Hugo Sánchez | 234 | 347 | Atlético de Madrid (54), Real Madrid (164), Rayo Vallecano (16) |
| 5 | Raúl González | 228 | 550 | Real Madrid C. F. (228) |
| 6 | Alfredo Di Stéfano | 227 | 329 | Real Madrid C. F. (216), R. C. D. Español (11) |
| 7 | César Rodríguez | 221 | 353 | Granada (23), Barcelona (190), Cultural Leonesa (3), Elche (5) |
| 8 | Karim Benzema | 219 | 415 | Real Madrid C. F. (219) |
| 9 | Enrique Castro Quini | 219 | 448 | Real Sporting (165), F. C. Barcelona (54) |
| 10 | Manuel Fdez. Pahiño | 212 | 278 | Celta de Vigo (57), Real Madrid (109), Deportivo de La Coruña (46) |
| 11 | Edmundo Suárez Mundo | 195 | 229 | Athletic Club (0), Valencia C. F. (186), C. D. Alcoyano (9) |
| 12 | Carlos Alonso Santillana | 186 | 461 | Real Madrid C. F. (186) |
| 13 | David Villa | 185 | 352 | Zaragoza (32), Valencia (107), Barcelona (33), Atlético de Madrid (13) |
| 14 | Juan Arza | 182 | 349 | Sevilla F. C. (182) |
| 15 | Guillermo Gorostiza | 178 | 256 | Athletic Club (106), Valencia C. F. (72) |
