| No. | Jugador | Equipo | Pick-6 | Temporada |
|---|---|---|---|---|
| 1 | DaRon Bland | Cowboys | 5 | 2023 |
| 2 | Ken Houston+ | Oilers | 4 | 1971 |
| Jim Kearney | Chiefs | 4 | 1972 | |
| Eric Allen+ | Eagles | 4 | 1993 | |
| 5 | Dick Harris | Chargers | 3 | 1961 |
| Dick Lynch | Giants | 3 | 1963 | |
| Herb Adderley+ | Packers | 3 | 1965 | |
| Lem Barney+ | Lions | 3 | 1967 | |
| Miller Farr | Oilers | 3 | 1967 | |
| Monte Jackson | Rams | 3 | 1976 | |
| Rod Perry | Rams | 3 | 1978 | |
| Ronnie Lott+ | 49ers | 3 | 1981 | |
| Lloyd Burruss | Chiefs | 3 | 1986 | |
| Wayne Haddix | Buccaneers | 3 | 1990 | |
| Robert Massey | Cardinals | 3 | 1992 | |
| Ray Buchanan | Colts | 3 | 1994 | |
| Deion Sanders+ | 49ers | 3 | 1994 | |
| Mark McMillian | Chiefs | 3 | 1997 | |
| Otis Smith | Jets | 3 | 1997 | |
| Jimmy Hitchcock | Vikings | 3 | 1998 | |
| Eric Allen+ | Raiders | 3 | 2000 | |
| Derrick Brooks+ | Buccaneers | 3 | 2002 | |
| Antrel Rolle | Cardinals | 3 | 2007 | |
| Nick Collins | Packers | 3 | 2008 | |
| Darren Sharper | Saints | 3 | 2009 | |
| Charles Woodson+ | Packers | 3 | 2009 | |
| Jackrabbit Jenkins | Rams | 3 | 2012 | |
| Charles Tillman | Bears | 3 | 2012 | |
| William Gay | Steelers | 3 | 2014 | |
| Marcus Peters | Rams/Ravens | 3 | 2019 | |
| 31 | Pug Rentner | Bos. Redskins | 2 | 1936 |
| Don Perkins | Packers | 2 | 1944 | |
| Bill Petrilas | Giants | 2 | 1944 | |
| Charley Brock | Packers | 2 | 1945 | |
| Tony Compagno | Steelers | 2 | 1947 | |
| Bill Schroeder | Chi. Rockets | 2 | 1947 | |
| Bill Blackburn | Cardinals | 2 | 1948 | |
| Joe Golding | Bos. Yanks | 2 | 1948 | |
| Dan Sandifer | Redskins | 2 | 1948 | |
| Emlen Tunnell+ | Giants | 2 | 1949 | |
| Warren Lahr | Browns | 2 | 1950 | |
| Bones Weatherly | Bears | 2 | 1950 | |
| Warren Lahr | Browns | 2 | 1951 | |
| Tom Landry+ | Giants | 2 | 1951 | |
| Otto Schnellbacher | Giants | 2 | 1951 | |
| Night Train Lane+ | Rams | 2 | 1952 | |
| Jack Butler+ | Steelers | 2 | 1954 | |
| Ken Konz | Browns | 2 | 1954 | |
| Bibbles Bawel | Eagles | 2 | 1955 | |
| J.C. Caroline | Bears | 2 | 1956 | |
| Milt Davis | Colts | 2 | 1957 | |
| Will Sherman | Rams | 2 | 1958 | |
| Bobby Franklin | Browns | 2 | 1960 | |
| Dave Webster | Dal. Texans | 2 | 1960 | |
| Erich Barnes | Giants | 2 | 1961 | |
| Dale Hackbart | Packers/Redskins | 2 | 1961 | |
| Sherrill Headrick | Dal. Texans | 2 | 1961 | |
| Bob Laraba | Chargers | 2 | 1961 | |
| Charlie McNeil | Chargers | 2 | 1961 | |
| Jerry Norton | Cardinals | 2 | 1961 | |
| Billy Stacy | Cardinals | 2 | 1961 | |
| Don Webb | Patriots | 2 | 1961 | |
| Bob Suci | Patriots | 2 | 1963 | |
| Pat Fischer | Cardinals | 2 | 1964 | |
| Rip Hawkins | Vikings | 2 | 1964 | |
| Dave Grayson | Raiders | 2 | 1965 | |
| Jerry Logan | Colts | 2 | 1965 | |
| Gus Otto | Raiders | 2 | 1965 | |
| Wayne Rasmussen | Lions | 2 | 1965 | |
| Tom Janik | Bills | 2 | 1966 | |
| Bob Jeter | Packers | 2 | 1966 | |
| Larry Wilson+ | Cardinals | 2 | 1966 | |
| Larry Hand | Lions | 2 | 1967 | |
| Jim Houston | Browns | 2 | 1967 | |
| Ken Houston+ | Oilers | 2 | 1967 | |
| Tom Janik | Bills | 2 | 1967 | |
| Bennie McRae | Bears | 2 | 1967 | |
| Eddie Meador | Rams | 2 | 1967 | |
| Jack Pardee | Rams | 2 | 1967 | |
| Warren Powers | Raiders | 2 | 1967 | |
| Dave Whitsell | Saints | 2 | 1967 | |
| Nemiah Wilson | Broncos | 2 | 1967 | |
| Joe Beauchamp | Chargers | 2 | 1968 | |
| Booker Edgerson | Bills | 2 | 1968 | |
| Miller Farr | Oilers | 2 | 1968 | |
| Ken Houston+ | Oilers | 2 | 1968 | |
| Spider Lockhart | Giants | 2 | 1968 | |
| Jack Pardee | Rams | 2 | 1968 | |
| Kenny Graham | Chargers | 2 | 1969 | |
| Eddie Meador | Rams | 2 | 1969 | |
| Bill Stanfill | Dolphins | 2 | 1969 | |
| Lem Barney+ | Lions | 2 | 1970 | |
| Jerry Logan | Colts | 2 | 1970 | |
| Mike Lucci | Lions | 2 | 1971 | |
| Jimmy Warren | Raiders | 2 | 1971 | |
| Lemar Parrish | Bengals | 2 | 1972 | |
| Skip Vanderbundt | 49ers | 2 | 1972 | |
| Dick Anderson | Dolphins | 2 | 1973 | |
| Tom Hayes | Falcons | 2 | 1973 | |
| Dave Elmendorf | Rams | 2 | 1974 | |
| Levi Johnson | Lions | 2 | 1974 | |
| Emmitt Thomas+ | Chiefs | 2 | 1974 | |
| Jackie Wallace | Colts | 2 | 1975 | |
| Tommy Casanova | Bengals | 2 | 1976 | |
| Prentice McCray | Patriots | 2 | 1976 | |
| Jim Merlo | Saints | 2 | 1976 | |
| John Rowser | Broncos | 2 | 1976 | |
| Lyle Blackwood | Colts | 2 | 1978 | |
| Scott Perry | Bengals | 2 | 1978 | |
| Lester Hayes | Raiders | 2 | 1979 | |
| Woodrow Lowe | Chargers | 2 | 1979 | |
| Jim Youngblood | Rams | 2 | 1979 | |
| Ray Griffin | Bengals | 2 | 1980 | |
| Cedric Brown | Buccaneers | 2 | 1981 | |
| John Harris | Seahawks | 2 | 1981 | |
| Darrol Ray | Jets | 2 | 1981 | |
| Hugh Green | Buccaneers | 2 | 1983 | |
| Dwight Hicks | 49ers | 2 | 1983 | |
| Johnnie Johnson | Rams | 2 | 1983 | |
| Kenny Johnson | Falcons | 2 | 1983 | |
| Mike Kozlowski | Dolphins | 2 | 1983 | |
| Rod Martin | Raiders | 2 | 1983 | |
| Ken Riley+ | Bengals | 2 | 1983 | |
| Eric Wright | 49ers | 2 | 1983 | |
| Dave Brown | Seahawks | 2 | 1984 | |
| Gill Byrd | Chargers | 2 | 1984 | |
| Vernon Dean | Redskins | 2 | 1984 | |
| Kenny Easley+ | Seahawks | 2 | 1984 | |
| LeRoy Irvin | Rams | 2 | 1984 | |
| Keith Simpson | Seahawks | 2 | 1984 | |
| Sam Washington | Steelers | 2 | 1984 | |
| Dirt Winston | Saints | 2 | 1984 | |
| Mike Harden | Broncos | 2 | 1986 | |
| Tom Holmoe | 49ers | 2 | 1986 | |
| Ronnie Lippett | Patriots | 2 | 1987 | |
| Carl Lee | Vikings | 2 | 1988 | |
| Erik McMillan | Jets | 2 | 1988 | |
| Eddie Anderson | Raiders | 2 | 1989 | |
| Thane Gash | Browns | 2 | 1989 | |
| Deion Sanders+ | Falcons | 2 | 1990 | |
| Marcus Turner | Cardinals | 2 | 1990 | |
| Erik McMillan | Jets | 2 | 1991 | |
| Henry Jones | Bills | 2 | 1992 | |
| Seth Joyner | Eagles | 2 | 1992 | |
| Audray McMillian | Vikings | 2 | 1992 | |
| Charles Mincy | Chiefs | 2 | 1992 | |
| Andre Collins | Redskins | 2 | 1994 | |
| Mo Lewis | Jets | 2 | 1994 | |
| Terry McDaniel | Raiders | 2 | 1994 | |
| Anthony Parker | Vikings | 2 | 1994 | |
| Stanley Richard | Chargers | 2 | 1994 | |
| Dewayne Washington | Vikings | 2 | 1994 | |
| Rod Woodson+ | Steelers | 2 | 1994 | |
| Larry Brown | Cowboys | 2 | 1995 | |
| Tim McDonald | 49ers | 2 | 1995 | |
| Ken Norton Jr. | 49ers | 2 | 1995 | |
| Aeneas Williams+ | Cardinals | 2 | 1995 | |
| Jason Belser | Colts | 2 | 1996 | |
| Aaron Glenn | Jets | 2 | 1996 | |
| Anthony Parker | Rams | 2 | 1996 | |
| Reggie Brown | Lions | 2 | 1997 | |
| Darren Sharper | Packers | 2 | 1997 | |
| Aeneas Williams+ | Cardinals | 2 | 1997 | |
| Eric Davis | Panthers | 2 | 1998 | |
| Percy Ellsworth | Giants | 2 | 1998 | |
| Sammy Knight | Saints | 2 | 1998 | |
| Darrin Smith | Seahawks | 2 | 1998 | |
| Shawn Springs | Seahawks | 2 | 1998 | |
| Zach Thomas+ | Dolphins | 2 | 1998 | |
| Dewayne Washington | Steelers | 2 | 1998 | |
| Rod Woodson+ | Ravens | 2 | 1998 | |
| Donnie Abraham | Buccaneers | 2 | 1999 | |
| Aaron Beasley | Jaguars | 2 | 1999 | |
| James Hasty | Chiefs | 2 | 1999 | |
| Mike Jones | Rams | 2 | 1999 | |
| George Teague | Cowboys | 2 | 1999 | |
| Grant Wistrom | Rams | 2 | 1999 | |
| Rod Woodson+ | Ravens | 2 | 1999 | |
| Sammy Knight | Saints | 2 | 2000 | |
| Jimmy Spencer | Broncos | 2 | 2000 | |
| Dre’ Bly | Rams | 2 | 2001 | |
| Zack Bronson | 49ers | 2 | 2001 | |
| Mike Brown | Bears | 2 | 2001 | |
| Dexter Coakley | Cowboys | 2 | 2001 | |
| Anthony Dorsett | Raiders | 2 | 2001 | |
| Ty Law+ | Patriots | 2 | 2001 | |
| Brock Marion | Dolphins | 2 | 2001 | |
| Chad Scott | Steelers | 2 | 2001 | |
| Otis Smith | Patriots | 2 | 2001 | |
| Brandon Spoon | Bills | 2 | 2001 | |
| Aeneas Williams+ | Rams | 2 | 2001 | |
| Marques Anderson | Packers | 2 | 2002 | |
| Tedy Bruschi | Patriots | 2 | 2002 | |
| Aaron Glenn | Texans | 2 | 2002 | |
| Justin Lucas | Cardinals | 2 | 2002 | |
| Deltha O’Neal | Broncos | 2 | 2002 | |
| Roy Williams | Cowboys | 2 | 2002 | |
| Rod Woodson+ | Raiders | 2 | 2002 | |
| Tedy Bruschi | Patriots | 2 | 2003 | |
| Phillip Buchanon | Raiders | 2 | 2003 | |
| Andre Dyson | Titans | 2 | 2003 | |
| Travis Fisher | Rams | 2 | 2003 | |
| Mike Minter | CAR | 2 | 2003 | |
| Jerome Woods | Chiefs | 2 | 2003 | |
| Kevin Mathis | Falcons | 2 | 2004 | |
| Darren Sharper | Packers | 2 | 2004 | |
| Lito Sheppard | Eagles | 2 | 2004 | |
| Takeo Spikes | Bills | 2 | 2004 | |
| Champ Bailey+ | Broncos | 2 | 2005 | |
| Karlos Dansby | Cardinals | 2 | 2005 | |
| Clinton Hart | Chargers | 2 | 2005 | |
| Cato June | Colts | 2 | 2005 | |
| Darren Sharper | Vikings | 2 | 2005 | |
| Ronde Barber+ | Buccaneers | 2 | 2006 | |
| Chris McAlister | Ravens | 2 | 2006 | |
| Jason Taylor+ | Dolphins | 2 | 2006 | |
| Vincent Fuller | Titans | 2 | 2007 | |
| Roderick Hood | Cardinals | 2 | 2007 | |
| Thomas Howard | Raiders | 2 | 2007 | |
| Mike McKenzie | Saints | 2 | 2007 | |
| Kevin Williams | Vikings | 2 | 2007 | |
| Jabari Greer | Bills | 2 | 2008 | |
| Rashean Mathis | Jaguars | 2 | 2008 | |
| Ed Reed+ | Ravens | 2 | 2008 | |
| Terrell Suggs | Ravens | 2 | 2008 | |
| Charles Woodson+ | Packers | 2 | 2008 | |
| Vincent Fuller | Titans | 2 | 2009 | |
| Tanard Jackson | Buccaneers | 2 | 2009 | |
| Derrick Johnson | Chiefs | 2 | 2009 | |
| Josh Wilson | Seahawks | 2 | 2009 | |
| David Bowens | Browns | 2 | 2010 | |
| Kelvin Hayden | Colts | 2 | 2010 | |
| Dwight Lowery | Jets | 2 | 2010 | |
| Dominique Rodgers-Cromartie | Cardinals | 2 | 2010 | |
| Brandon Browner | Seahawks | 2 | 2011 | |
| Chris Houston | Lions | 2 | 2011 | |
| Aqib Talib | Buccaneers | 2 | 2011 | |
| Charles Tillman | Bears | 2 | 2011 | |
| Lance Briggs | Bears | 2 | 2012 | |
| Zach Brown | Titans | 2 | 2012 | |
| Darius Butler | Colts | 2 | 2012 | |
| Chris Harris Jr. | Broncos | 2 | 2012 | |
| Captain Munnerlyn | Panthers | 2 | 2012 | |
| Harrison Smith | Vikings | 2 | 2012 | |
| Demorrio Williams | Chargers | 2 | 2012 | |
| Eric Berry | Chiefs | 2 | 2013 | |
| Karlos Dansby | Cardinals | 2 | 2013 | |
| Mason Foster | Buccaneers | 2 | 2013 | |
| DeAngelo Hall | Redskins | 2 | 2013 | |
| Tim Jennings | Bears | 2 | 2013 | |
| Captain Munnerlyn | Panthers | 2 | 2013 | |
| Bruce Irvin | Seahawks | 2 | 2014 | |
| Jackrabbit Jenkins | Rams | 2 | 2014 | |
| Rashad Johnson | Cardinals | 2 | 2014 | |
| Danny Lansanah | Buccaneers | 2 | 2014 | |
| Julius Peppers+ | Packers | 2 | 2014 | |
| Aqib Talib | Broncos | 2 | 2014 | |
| Karlos Dansby | Browns | 2 | 2015 | |
| Reshad Jones | Dolphins | 2 | 2015 | |
| Josh Norman | Panthers | 2 | 2015 | |
| Marcus Peters | Chiefs | 2 | 2015 | |
| Aqib Talib | Broncos | 2 | 2015 | |
| Eric Berry | Chiefs | 2 | 2016 | |
| Malcolm Jenkins | Eagles | 2 | 2016 | |
| Deion Jones | Falcons | 2 | 2016 | |
| Bradley Roby | Broncos | 2 | 2016 | |
| Justin Coleman | Seahawks | 2 | 2017 | |
| Jackrabbit Jenkins | Giants | 2 | 2017 | |
| Eddie Jackson | Bears | 2 | 2018 | |
| Alec Ogletree | Giants | 2 | 2018 | |
| Stephon Gilmore | Patriots | 2 | 2019 | |
| Erik Harris | Raiders | 2 | 2019 | |
| Troy Hill | Rams | 2 | 2020 | |
| Trevon Diggs | Cowboys | 2 | 2021 | |
| Rasul Douglas | Packers | 2 | 2021 | |
| Mike Edwards | Buccaneers | 2 | 2021 | |
| Kyle Dugger | Patriots | 2 | 2022 | |
| Kendall Fuller | Commanders | 2 | 2022 | |
| Jack Jones | Patriots/Raiders | 2 | 2023 | |
| Kenny Moore | Colts | 2 | 2023 | |
| Andrew Van Ginkel | Vikings | 2 | 2024 | |
| Devin Bush Jr. | Browns | 2 | 2025 |
